Castilla–La Mancha is an interesting case study to be investigated for spatial mobility and its relationship to Twin Transition, as it constitutes a peripheral/distant area of the multicentric metropolitan region of Madrid. Castilla–La Mancha, have considerably increased their work-related intermunicipal flows during the last three decades. These regions keep changing from predominantly rural areas into areas that exhibit mixed rural–metropolitan behaviors, they are increasingly influenced by metropolitan overflows, which are predominantly integrating non-centrality municipalities and they experience a commuting reconfiguration towards multidirectional patterns.